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Dr. Basik’s laboratory is part of the Montreal Centre for Experimental Therapeutics in Cancer, located at the Jewish General Hospital and thus part of the Lady Davis Institute for Medical Research. Dr. Basik is a surgical oncologist, and member of the Depts of Oncology and Surgery at McGill University. The laboratory’s area of interest is investigating gene expression and DNA changes in breast and colon cancers. Using modern microarray technology, we are investigating the relationship between DNA copy number changes and gene expression across the genome in both cell lines and primary tumors. One goal is to find genes that are overexpressed as well as amplified in these cancers. These genes will then be candidate targets for novel anti-cancer therapies. They will be functionally validated using small interfering RNA approaches, and clinically validated using tissue microarrays constructed at the laboratory. Another goal is to discover novel tumor suppressor genes using a combination of microarray technologies and manipulations of the nonsense-mediated RNA decay system. Both novel tumor suppressor genes and amplified genes will also be studied as potential new diagnostic markers in breast and colon cancer. We have a special focus on markers of breast cancer metastasis, specifically chemokines and their receptors (CXCR4). We are also investigating mechanisms of resistance to novel biologics such as herceptin. Finally we are part of the FRSQ Reseau de Cancer axe cancer du sein/ovaire, and as such are actively participating in a province-wide breast tumor banking as well as placing primary breast tumor into primary culture. A particular interest is stromal-epithelial interactions active in breast tumor biology.

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© 2007 Jewish General Hospital - Lady Davis Institute
Basik Research Lab - E421
3755 Côte Ste Catherine Road
Montreal, Quebec H3T 1E2
514-3408222 x 2782
Last Updated: 10/02/2007